Pseudoseizures–Achieving Accurate Diagnosis

You are called by jail deputies to see a patient who had a short seizure and now is having another. The patient has only been in jail for a couple of days. He did not mention a seizure disorder at booking. He was arrested on a meth charge.

When you arrive, the patient is on the floor of the dorm, unresponsive and twitching. What do you do?

The diagnostic problem here is whether this is a true epileptic seizure or whether this is one of the various kinds of pseudoseizure. Accurate diagnosis is important because the treatment for the two conditions is so different.

Two epileptic seizures in short succession should make you think about status epilepticus and calling an ambulance. Even if the seizure stopped and you didn’t send this patient to the hospital, you would want a detailed examination in clinic to determine why these seizures happened. Is this a manifestation of some type of withdrawal, such as alcohol withdrawal? Does he have a seizure disorder that he did not tell you about before? You might consider a benzodiazepine like Ativan acutely and an anti-seizure drug like phenytoin. Down the road, you might want to do a work up, such as blood work, an EEG and maybe even a specialist referral.

On the other hand, if this is a seizure look-alike such as a Psychogenic Non-Epileptic Seizure (PNES), your treatment algorhythm would look much different. Then, your goal is just to stop the event and hopefully, be able to intervene in some way (counseling?) to prevent these from happening in the future. No ER visit. No seizure drugs. No EEG etc.

To get the diagnosis wrong—either way—would be to treat the patient inappropriately and perhaps even to harm the patient. So, accurate diagnosis is paramount.

It turns out that there are several observations, “field tests” and tools that can be useful in differentiating true epileptic seizures from pseudoseizures. There are even lab tests that can be useful! Some of these are much more reliable and accurate than others and I will point these out.

Pseudoseizures look different than true epileptic seizures. Know the key differences.

The two most important differences between pseudoseizures and grand mal epileptic seizures are:

1. During a true epileptic seizure, the patient’s eyes are open and deviated (looking off to one side or the other). The eyes of a patient having a pseudoseizure are almost always closed. And if you open the pseudoseizure patient’s eyelids with your fingers, the pupils will not be deviated—rather, they will be looking straight ahead.

2. Patients who have had a true epileptic seizure will invariable have a postictal state of confusion after the seizure ends. The postictal state typically lasts much longer than the original seizure. Patients who have had pseudoseizures do not usually exhibit postictal confusion.

Memorize these two key differences! Everything else is less important.

However, other common differences between a true epileptic seizure and a pseudoseizure can also be useful in certain cases:

3. Epileptic seizure patients go through a tonic-clonic movement pattern: flexion of the limbs followed by extension. The arms are held close to the body. Pseudoseizure patients do not follow this pattern. Often, their arms are held akimbo away from the body. They also may also do other movements not seen in a true epileptic seizure, such as rolling side to side, pelvic thrusting, rolling the head back and forth, etc.

4. True epileptic seizures build to a crescendo then abate. Pseudoseizures tend to wax and wane.

5. True epileptic seizure patients commonly bite their tongues and sometimes lose continence. Pseudoseizure patients rarely do either. (Though I once dealt with a particularly skillful patient with factitious disorder who made it a point always to bite his tongue and wet his pants when he staged an event).

6. Grand mal seizure patients usually get hypoxic transiently during a seizure since their chest muscles seize, as well. You can demonstrate this with a pulse oximeter (if you have one handy during the event). Epileptic seizure patients will often show mild hypoxia. Pseudoseizure patients’ pulse oximeter readings will remain normal.

7. Blood chemistries following a true epileptic seizure will often show an elevated CPK(due to muscle spasms), an elevated anion gap and depressed serum bicarb (due to lactic acidosis) and, most oddly, elevated prolactin levels.

True seizure patients are unconscious!

This is the single most important difference between a true Epileptic Seizure and a pseudoseizure: patients having an epileptic seizure are unconscious! Pseudoseizure patients may be unresponsive, but they are not unconscious.

20140219This insight is, of course, useful when a patient is carrying on a conversation during a “seizure” event–like the patient who once said to me while she was shaking (with her eyes closed, by the way): “I’m having my seizure now! You will need to give me Xanax. It’s the only thing my doctor found that helps.”

Most pseudoseizure patients, however, do not give themselves away so easily. They are more typically unresponsive: You can talk to them, shake them—no response.

In my emergency medicine training, I was taught many ways to determine whether a patient was truly unconscious or not. One method was to take the patient’s hand and drop it over their face. If the patient is unconscious, the hand will smack them in the face. If the patient is not unconscious, the hand will invariably slide away to the side. I personally don’t use this procedure.

A method more commonly taught in training programs is the sternal rub. It is so commonly taught that I bet almost everyone reading this is aware of this test! The sternal rub consists of using your knuckles to rub forcefully up and down the patient’s sternum. The idea is that this hurts, and if the patient is not unconscious, he will wake right up and say stop! Unfortunately, the sternal rub has a couple of problems. First, how painful it is depends on how forcefully one rubs, on how much fat “padding” the patient has and on the patient’s tolerance to pain. I have seen the sternal rub fail on many occasions for one or more of these reasons.

Because of this, I was taught in my residency several other even more painful procedures to inflict on unresponsive patients—nerve roots to poke, pressure points to grab ala Mr. Spock, and—well, you get the point. Similarly, I’ve seen health care providers use foley catheters and large bore IVs to “wake up” a patient they suspected of having a pseudo-event.

However, the more important problem with all of these painful techniques is that they are ethically questionable. Intentionally hurting our patients? I don’t know. Such procedures especially tend to be misused when the medical provider feels angry at the patient for “faking” a seizure. I’ve seen “caregivers” become quite cruel and even borderline sadistic applying such painful procedures. I personally am uncomfortable with these techniques . . . especially when there is a better alternative.

The single best test to distinguish pseudoseizures from true epileptic seizures is the ammonia capsule, properly used.

Contrary to the sternal rub, I have never seen an ammonia capsule fail. No conscious person can inhale ammonia fumes and not react. It is a reflex as much as anything. Plus ammonia has the advantage of being unpleasant but not painful.

The trick is knowing how to use ammonia capsules correctly. Like any other tool, ammonia can be used effectively or misused. But I have never seen or read anywhere where the proper use of ammonia capsules is taught. I intend to rectify this sad situation!

Next on JailMedicine: A Pictorial Tutorial on the Proper Diagnostic use of Ammonia Capsules

Mandatory disclaimer: I have presented here my own opinions, which I have developed as a result of my training and experience. Feel free to disagree! I might be wrong. But if you do disagree, please explain why in comments!

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13 thoughts on “Pseudoseizures–Achieving Accurate Diagnosis

  1. AvatarAl Cichon

    Absolutely on target! Thoughts:
    1. Whenever possible medical records are golden – most ‘true’ seizure patients have lots and a pharmacy history (not always true – just had a young very non-compliant seizure patient; bless the ED Doc who wrote that in the record.
    2. Another irritant procedure – less likely to be abused – rubbing up under the nasal septum – not much force required but quite the irritant
    3. Explaining it to corrections officers is a real challenge – ‘Pseudo’ = fake right? or Why aren’t you giving him / her medicine?
    4. Last thought – Valium (not Xanax – but Dilantin is better) may be a good idea until the differential is resolved

  2. AvatarDonna

    I quite enjoyed your article. I have trained the correctional staff here to use Ammonia Capsules in obtaining information for me. (Seizures have a funny way of happening after the Nurse has gone home for the evening. ). The officers seem to feel more comfortabe using the capsules verse actually having to touch the inmate in their presented state. Less chance of the inmate getting harmed while determining their status.

  3. AvatarPatty Workman NP

    Yes, yes and YES! Totally on point. Good job!
    And I find that once I give the person the “good news” that they don’t have seizures, they quit trying to use that ploy. At least at our jail. All bets are off when they go out to court or other facilities.

  4. AvatarErin Robertson MD

    Totally incorrect and clinically irresponsible. There are several flavors of true seizures: simple partial, complex partial, generalized, etc, not all of which can be confirmed via a 1-hour EEG, serum testing, eye deviation, etc. If a patient is undergoing any kind of chemical withdrawl, this would complicate any presentation of post-ictal confusion. The absolute worst thing you can do is brush off true seizure activity as “pseudo,” resulting in mismanagement, potential harm to the patient, and custody officer bias. Memorize this: Use trustworthy resources. Pseudoseizures are absolutely a diagnosis of exclusion. 1% of the general population will have a seizure at one point in their lifetime.

    1. AvatarJeffrey Keller MD Post author

      Thanks for the comment Erin. In the my last post on the subject, I made the following points: 1. The absolute worst mistake that a clinician can make in evaluating these patients is to diagnose a pseudoseizure–and be wrong. 2. Approximately 1/3 of patients who have pseudoseizures also have real epileptic seizures, as well. 3. In order to reach the right diagnosis and to treat the patient correctly, it is important to get rid of all of the negative emotional baggage that we tend to have when we think a patient is “faking.” I assume you agree with each of those statements. In addition, I would add that to treat a Psychogenic Non-Epileptic Seizure or a factitious event as if it were a real epileptic seizure is also a mistake that can result in harm to a patient, both in the short and long term. I’ve seen it happen.

      1. AvatarKimberly Myers

        Dr. Keller I totally agree, I have seen a pt continue with a pseudo seizure on a new MD to corrections and he gave so much Ativan waiting on the ambulance that the inmate went into respiratory arrest. This pt in the past had exhibited multiple pseudo seizures and upon any new provider would try again to get loaded on Ativan. Thank goodness he lived.
        KM NP

        1. AvatarJeffrey Keller MD Post author

          Excellent point, Kim! There are potential serious consequences to getting this diagnosis wrong–either way!

  5. Avatarstephanie

    These articles you’ve written are so helpful. I’m an EMT working at a county jail and while I have a baseline knowledge of seizures, I’m not use to people faking it so much. I constantly worry about being biased and not properly treating a pt but these articles have really helped me understand how to handle things moving forward. This shift I had 3 pseudo-seizures and it’s generally a favorite act for the inmates so there will be many more.

    Again thanks so much! Glad to have found this site!

  6. Pingback: The M-Word–Malingering | Jail Medicine

  7. AvatarDr. Ja’net Blackwell PhD, LPC, NCC

    I disagree with some statements here. Not all NES patients are faking it as many of you claim. I think you should do more research on the topic. People that have NES have potentially gone through some form of psychological trauma or handle stress and anxiety in different manners.

    1. AvatarJeffrey Keller MD Post author

      Thank you Ja’net! As I have written many times, health care providers should almost never assume that a patient is “faking” or “malingering.” That road leads to disaster.

  8. AvatarJo Ellen Hirsch, MD

    Dr. Keller – Excellent article. I’m an internist, currently working in an opioid treatment setting. I spent 8 years as an internist in a military clinic caring for soldiers, military retirees, and military dependents. From time to time I would be called to the lobby because of a person suspected of having seizure activity. One thing that was helpful to me was to very gently hold one arm by the wrist. That would generally extinguish the tonic clonic motions. In residency, I saw enough patients with epileptic seizures to note that the T/C motions would continue no matter what. No experience whatsoever with seizures induced by drugs of abuse and probably wouldn’t be able to recognize them.


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