Monthly Archives: November 2012

Interesting Article of the Week Plus Price Check!

An acquaintance complained to me recently that he was struggling to afford his medications, which cost him a couple of hundred dollars a month.  I looked at his medication list and saw (among other examples) that he had been prescribed the statin Crestor, which costs $5.00 a pill, even though generic simvastatin costs just 3 cents a pill!  He was prescribed the Angiotensin Receptor Blocker (ARB) Benicar ($4.26 a pill) even though the generic ARB losartan costs 7 cents a pill.

When I called the prescribing doctor on behalf of this patient, the doctor readily changed his prescriptions to the more affordable brands.  But why would he prescribe expensive stuff his patient couldn’t afford in the first place?  That is the subject of our interesting article of the week.

Ann Pharmacother. 2012 Feb;46(2):200-7. Epub 2012 Feb 7.

Assessment of prescribers’ knowledge of the cost of medications.

Cogdill BNappi JM.

(Click here to go to the PubMed citation)

This study assessed physician and medical students’ knowledge of drug prices. The prescribers in the study did amazingly poorly on a test of their knowledge of drug prices.  That didn’t surprise me.  What did surprise me, however, that the prescribers seemed not to care that they did not know drug prices! They didn’t seem to think it was important.  These prescribers also routinely prescribed medications without knowing or checking whether their patients had insurance that would cover the drug.

This attitude may be common (common?  Almost universal!) in the outside world of medicine, but it has no place in Correctional Medicine.  We prescribers who work in correctional facilities need to have an idea of what drugs cost.

  1. Most of our patients will eventually get out of our jails and prisons.  Most of them will not have medical insurance.  We need to prescribe medications that they will be able to afford.
  2. Besides being medical practitioners, we also are stewards of the money the county or state spends on medical care within our facility.  Every dollar that we spend needlessly is a dollar that cannot be used for something else.
  3. Besides looking for effective medications, we also need to look for medications with high value.  Value is a concept that seems to have been forgotten in modern medicine, as practiced in the United States at least.

What is the Value of a Drug?

The “Value” of a drug can be defined as the benefit of that drug divided by its cost.  If medication A and medication B both achieve the same result, but medication A is 20 times more expensive than medication B, then medication B has 20 times more value.

Sometimes, new and expensive drugs are touted by drug reps as having, say, “17% improved relative benefit” over the old, generic drug.  Almost always, these claims are unfounded or the difference is clinically meaningless.  But even if it is true, the generic drug  will still usually have more Value.  Nexium versus omeprazole is a good example.  AstraZenica, the maker of Nexium, claims that Nexium provides slightly better stomach acid control than does omeprazole.  Most experts do not believe this, but even if it is true, omeprazole costs 10 cents a pill, whereas Nexium costs $6.15 a pill.  Is Nexium 61 times more effective than omeprazole?  The answer is, of course, no.  Instead, omeprazole is 60 times more Valuable than is Nexium.

So why is Nexium one of the best selling drugs in the world?  The Interesting Article of the Week has the answer:  Because U.S. doctors don’t know how much Nexium costs and they don’t care.  Sad.

Let’s make sure that we Correctional Medical Specialists know the basic price of the drugs we use.  To do this, we need a source.  Your pharmacy is one source.  Have your pharmacy do a price comparison for you on a different category of drug every month.  You can also find the acquisition cost of most medications online.  Here is the one I use:  The Idaho Average Acquisition Cost Drug List.  It is published by Idaho Medicaid and is updated every two weeks.  You can find it here.

Price Comparisons

Here is the Average Acquisition Cost Drug List price for the medication classes I discussed in today’s post:

Angiotensin Receptor Blockers

Generic Drugs Brand Name Drugs Price per Pill
Losartan (Cozaar)50mg $0.07
Irbesartan (Avapro)150mg $1.83
Atacand (candesartan) 4mg $2.79
Benicar (olmesartan) 40mg $4.26
Diovan (valsartan) 40mg $2.67
Micardis (telmisartan) 40mg $4.02

Comment:  If you have to use an ARB rather than an ACE inhibitor, why would you use anything other than losartan (at least until the price of irbesartan falls to comparable levels?)

Statins

Generic Drugs Brand Name Drugs Price per Pill
Atorvastatin (Lipitor) 20mg $0.22
Simvastatin (Zocor) 20mg $0.03
Pravastatin (Pravachol) 20mg $0.07
Crestor (rosuvastatin)20mg $4.99
Livalo (pitavastatin) $4.14

Comment:  Note that atorvastatin is rapidly falling in price and will soon be comparable to simvastatin and pravastatin.  Lipitor was once the top selling drug in the world!

Proton Pump Inhibitors

Generic Drugs Brand Name Drugs Price per Pill
Omeprazole (Prilosec) 20mg $0.10
Lansoprazole (Prevacid) 15mg $1.27
Pantoprazole (Protonix) 20mg $0.09
Nexium (esomeprazole) 20mg $6.15
Dexilant (dexlansoprazole) 30mg $4.67
Aciphex (rabeprazole) 20mg $8.61

Comment:  Note that pantoprazole (Protonix) is now even a little less expensive than is omeprazole!  And remember that omeprazole also has an OTC formulation, so you can put it on your commissary, so inmates won’t have to come to you to get it.

Do you track drug prices at your facility?  How do you do it?  Please Comment!

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Reader Question: Diabetic Malingering Part 3

Janet, great correctional nurse, Ada county Jail, Boise

Dr. Kay Haw submitted the following question:

“I would like to know your thoughts on the ability to forcibly provide insulin coverage on a diabetic inmate whose sugars are out of control and is refusing blood sugar checks and insulin administration.”

This is a great question that I should have answered as part of the Diabetic Malingering series found here and here.  The question here is whether an inmate has a right to refuse medical care, even if doing so could result in harm.  In general, inmates retain the right to refuse medical care, as long as they are competent to do so and as long as the refusal is informed (more on that later). However, this right of refusal is not inalienable and  depends on clinical circumstances, such as how much harm the patient faces by the refusal, the reason the patient has for refusing and the patient’s competence.

In the case of refusing insulin, the risk the patient faces depends on whether the patient is a Type 1 diabetic or a type 2 diabetic. A Type 1 diabetic will eventually die without insulin and may lapse into a diabetic keto-acidosis coma in as soon as 3-4 days.  Type 2 diabetics, on the other hand, will not die without insulin.  They still make their own insulin.  They are insulin resistant but not insulin dependent.  Some are prescribed insulin to keep their blood sugars down, but they do not need insulin to survive.

Refusal of Insulin by a Type 2 Diabetic

So let’s first take the simpler case of a Type 2 diabetic who refuses to take insulin.  Since he does not need insulin to survive, and since insulin is not the only treatment option available, the refusal of insulin is analogous to the same patient refusing a diabetic diet.  It may not be in his best interest to refuse insulin (or a diabetic diet) but the patient has the right to refuse these treatments as long as the refusal is an informed refusal.  An informed refusal entails that someone, usually the jail practitioner, informs this patient of the potential harm that might ensue as a result of refusing medical care.  I would talk about the risk of heart attacks, strokes, kidney failure, blindness, foot amputations and every other complication of diabetes I can think of.  Besides warning him of the possible consequences of his refusal, I might just scare him enough to reconsider.  The threat of impotence seems to work particularly well in the scaring department!

After this, assuming that the patient continues to refuse care, I inform him that he can change his mind at any time and document the conversation thoroughly in the medical record.  There are times when you can be brief in your medical documentation but this is not one of them.  You need to document the risks you discussed with the patient, the fact that he refused and that you told him he could change his mind.  That’s the easy case.

Refusal of Insulin by a Type 1 Diabetic

The refusal of insulin by a Type 1 diabetic is a totally different case since type 1 diabetics are dependent on insulin to survive.  Without insulin, they can lapse into a diabetic coma in as little as 3-4 days.  The threat is real and immediate. The first question to ask a Type 1 diabetic who is refusing insulin is whether he understands this and whether he is intending to commit suicide.  In fact, for Type 1 diabetics, the conversation on adverse consequences can be much shorter than for Type 2 diabetics.  All you really have to say is “Without insulin, you will die.  Maybe within days.  Do you understand this?”

If the patient continues to refuse insulin despite this warning, my personal opinion is that, in most cases, this jail inmate should be forcibly restrained and given insulin despite his refusal.

“Wait!” you might be saying.”What about the inmate’s right to an informed refusal of medical care?” Well, there are several  issues here that bear on my decision to override this particular inmate’s right to refuse care.

1. What is the inmate’s motivation for refusing this life-saving medical intervention? There is a difference between a patient who is refusing life-or-death medical care for religious reasons (Like Jehovah’s Witness refusing blood products) versus refusing due to a trivial protest of jail policies or wanting to commit suicide.   I do have not have much respect for a patient who is refusing insulin as a method of manipulation.  And inmates do not have an innate right to manipulate.

2.  Inmates do not have a right to commit suicide.  Just as an inmate does not have the right to kill themselves by refusing oxygen (by wrapping a sheet around their neck), they also don’t have the right to kill themselves by refusing insulin.

3.  The threat to a Type 1 diabetic’s health of refusing insulin is immediate.  Without insulin, they may lapse into a coma within days.  There often is not enough time to adjudicate the question in court.  If, instead of wanting to commit suicide by refusing insulin, an inmate wanted to commit suicide by refusing food and starving to death, there would be plenty of time to get a judges opinion.  Death by starvation takes weeks.  Death by diabetic coma takes days.  I need to act now.

4. The solution to this dilemma is relatively quick and easy.  In order to keep a Type 1 diabetic alive, all we really need to give them is long acting basal insulin, either Levemir or Lantus, once a day.  And patients need only be restrained for literally seconds, just long enough to get a blood sugar and give insulin.  Patients won’t be well controlled with just Lantus, but it will keep them alive long enough to go to court, if necessary. More typically in my experience, after the first forced shot, patients usually change their mind and again accept diabetic care.

5. Finally, incarcerated inmates, to some degree, have lost absolute autonomy to make their own decisions.  Just like an inmate cannot choose what to eat or to wear, they do not have an inalienable right to refuse medical care when in jail.  Jails, prisons and juvenile facilities have some degree of guardianship over incarcerated inmates and also have not only the right, but the responsibility to protect the well being of the inmate as well as the safety and security of the institution.

“I’ll take insulin, but I refuse to allow you to take blood sugars.”

What about the patient who accepts insulin, but refuses to allow blood sugar checks?  Again, in my mind, this boils down to the risk the patient faces by this refusal.  Since a shot of insulin can potentially kill a person whose blood sugar is low, knowledge of the blood sugar is mandatory to be able to give insulin safely.  I would not allow a patient to accept insulin but refuse blood sugar checks.  They must go together.

What I have written here is my own opinion.  I freely admit that smart people might just disagree with me!  In fact, I might be wrong!  You should discuss this potential situation with your facitily’s legal counsel and administration so you know in advance what you are going to do when the time comes.  And it will happen!  This is not that uncommon of a situation.

What would you do in the case of a Type 1 diabetic who is refusing insulin?  Please comment!

Special Thanks to David Tatarsky, General Counsel to the South Carolina Department of Corrections, for teaching me how to look at this case from a legal perspective.  Of course, if I have made a mistake, it is my mistake, not his!

 

Essential Pearls from Essentials

Essentials of Correctional Medicine was held last week in Salt Lake City, Utah and included some great talks.  Today’s post is a list of Pearls I gleaned from the conference speakers.

The definition of a “Pearl” is a bit of pithy and insightful information that can be communicated in one or two sentences. Hopefully, it is also something that you have not thought of yet and will change your practice for the better.

I ran into several Pearls at the Essentials conference. Here is a sampling (in no particular order): Continue reading

A Daring Plan for Discharge Meds!

One of the “systems” problems that all jails have to deal with is what to do with medications when a patient is released from jail.  Prisons deal with this issue as well but tend to have fewer headaches than jails, mainly because they know exactly when inmates are leaving the facility and can plan ahead.  In jails, often we don’t know exactly when a patient will leave.  Continue reading